Experimental data reported a lack of estrogen/progesterone receptors in CRC.[11] However, a prospective study showed that parity may reduce the risk of colon cancer among women as a result of modifications of hormone profiles.[12] Possible mechanisms include hormonal effects on bile acid metabolism[12,13] and immunologic influences of ABO-incompatible fetal antigens.[14]. This evidence concerns the gene PGR and malignant colon neoplasm.