Nevertheless, given the positive results of this study in male mice and the fact that over 60% of patients with AD are female (“2015 Alzheimer’s disease facts and figures,” 2015), it would be important clearly to test the assumption that aged female PDAPP mice would also demonstrate cognitive and pathology benefits from reducing APP cleavage by BACE1. This evidence concerns the gene BACE1 and early-onset autosomal dominant Alzheimer disease.