For example, SelP expression is downregulated by TNFα stimulation of 3T3-L1 cells [49], by IL-6 in human hepatoma cells [47], and studies of the human SelP promoter have shown it is responsive to IL-1β, IFNγ and TNFα in HepG2 cells [50]. The gene discussed is TNF; the disease is hepatocellular carcinoma.