In addition, our past studies with a rainbow trout liver-derived cell line (RTL) supplemented with the same Se forms/ dose range used here modulated the expression of another selenoprotein, thioredoxin reductase (trxr)3a, that is known to be an antioxidant and can respond to bacterial infection in head kidney (HK) and spleen of rainbow trout [48]. Here, PRDX5 is linked to bacterial infectious disease.