Concerning the prognostic value of β1 integrin extracellular ligands such as fibronectin, collagens and laminins as well as intracellular signaling mediators such as FAK, a small set of studies revealed a correlation between an upregulation of these proteins or increased copy numbers with HNSCC patients survival [54–56]. The gene discussed is FN1; the disease is head and neck squamous cell carcinoma.