Significantly higher OS was obtained for patients with low cN stage (p = 0.002), supraglottic tumors (p = 0.020), low WHO stage (p = 0.001), non-smokers (p = 0.005), p16 positive tumors (p = 0.005) and short treatment time (p = 0.048). The gene discussed is CDKN2A; the disease is supraglottis neoplasm.