Our model is based on expression of either human wild-type or the familial neurodegenerative tauopathy, frontotemporal dementia with parkinsonism linked to Chromosome 17 (FTDP-17)–associated mutant tau using the GAL4/UAS bipartite expression system with the panneuronal elav-GAL4 driver [27]. The gene discussed is LGALS4; the disease is semantic dementia.