To examine the specificity of the interaction between Lrrk and tau, we examined an unrelated model of age-dependent neurodegeneration in Drosophila. We expressed mutant SCA3, a polyglutamine-expanded protein linked to spinocerebellar ataxia type 3 (Machado—Joseph disease), using the panneuronal driver elav-GAL4 and assessed Kenyon neuron degeneration, as we have described previously [29,34]. The gene discussed is MAPT; the disease is Spinocerebellar ataxia type 3.