The results of the MR analysis, reported as odds ratios (ORs) of stroke per SD unit increase in each iron status biomarker, found a detrimental effect of an increased iron status on risk of any stroke for serum iron (OR, 1.07; 95% CI, 1.01–1.14; P=0.03), (log-transformed) ferritin (OR, 1.18; 95% CI, 1.02–1.36; P=0.03), and transferrin saturation (OR, 1.06; 95% CI, 1.01–1.11; P=0.02). The gene discussed is TF; the disease is stroke disorder.