A further case-control study investigating ischemic stroke subtypes found no significant association between risk of atherothrombotic, small vessel and cardioembolic stroke, and iron status biomarkers, including ferritin and transferrin saturation.8 The diverse population demographics and possible confounding factors may contribute to the heterogeneity of the results, along with the possibility of a nonlinear effect of iron status on stroke risk. The gene discussed is TF; the disease is ischemic stroke.