There was no significant effect of iron status on risk of large artery stroke (serum iron OR, 0.95; 95% CI, 0.81–1.12; P=0.54; [log-transformed] ferritin OR, 0.82; 95% CI, 0.55–1.22; P=0.32; transferrin saturation OR, 0.95; 95% CI, 0.84–1.08; P=0.41; transferrin OR, 1.12; 95% CI, 0.91–1.38; P=0.28). The gene discussed is TF; the disease is large artery stroke.