In malaria, IL‐10 can come from both innate and adaptive immune cells, including Th1‐derived regulatory T cells that coproduce IFN‐γ and IL‐10,87, 88, 89 and plays an essential role in both adaptive humoral immunity (promoting differentiation of T‐bet+ germinal center B cells)90, 91 and limiting tissue damage.92, 93, 94. The gene discussed is IFNG; the disease is malaria.