MAPT and Alzheimer disease: Using τ306 and previously described 3R tau RT-QuIC conditions [37], we saw more rapid seeding with 10−3 or 10−4 dilutions of AD brain homogenate relative to 10−3 dilutions of brain tissue that showed no tau pathology and was being used as control tissue harvested from individuals diagnosed as having Diffuse Lewy body Dementia (DLBD) (Online Resource Fig. 2a, c).