The diabetic rats significantly indicated increased hypertrophy, QT and QTcintervals and decreased Left ventricular systolic pressure (LVSP), Leftventricular developed pressure (LVDP), rate pressure product (RPP), Maxdp/dt, and min dp/dt (±dp/dt max), heart rate, superoxide dismutase(SOD), glutathione peroxidase (GPx) and catalase in the heart. Here, SOD1 is linked to hypertrophy.