The vWF is a glycoprotein encoded by the short arm of chromosome 12 and can becombined with collagen fibers and platelets; it is closely related to a range ofcardiovascular diseases such as atherosclerosis, acute coronary syndrome, and atrialfibrillation.27 vWFdirectly stimulates vascular smooth muscle cell proliferation, resulting in a directdose-response effect. This evidence concerns the gene VWF and glycogen storage disease VI.