In this study, we found (a) Sanhuang Xiexin decoction could significantly decrease the levels of inflammatory factors including Fib, PAgT, CRP, and TMAO in ischemic stroke patients; (b) in addition, Sanhuang Xiexin decoction could also reduce the syndrome of fire‐heat scores; (c) moreover, Sanhuang Xiexin decoction could reduce the incidence of ischemic cerebrovascular events in ischemic stroke patients within 3 and 6 months after endovascular intervention treatment as well. This evidence concerns the gene CRP and ischemic stroke.