By multivariate logistic regression analysis with adjustments for sex, age, drinking and smoking status, SNPs rs6504593 and rs1049109 had a significant association with colorectal cancer susceptibility in the additive model (OR = 1.19, 95% CI = 1.04‐1.36, P = 0.011 for rs6504593 in IGF2BP1 and OR = 1.23, 95% CI = 1.07‐1.41, P = 0.004 for rs1049109 in ALPP). Here, ALPP is linked to colorectal cancer.