Dysfunction of p62 is also involved in the pathogenesis of human diseases, for example, aberrant accumulation of p62‐ positive aggregates structures has been detected in patients with liver disorders, tumors, and neurodegenerative diseases.36 It has also been shown that B. cenocepacia (B. cepacia) infected cystic fibrosis patients that leads to severe lung inflammation and lung tissue destruction (37). This evidence concerns the gene SQSTM1 and neurodegenerative disease.