Spleen lysates of most mice showed an overall 2‐5 folds increase in p62 levels, and variable bacterial counts (cfu) regardless of the route of infection (Figure 5A–C, and Table 2), suggesting that similar to B. mallei infections, functional autophagy was reduced by B. pseudomallei infection of BALB/c mice leading to an accumulation of p62. This evidence concerns the gene SQSTM1 and infection.