In our previous studies, GAS5 expression in A375 cells downregulated the expression of the matrix metalloproteinases (MMPs) gelatinase A (MMP2) and gelatinase B (MMP9), inhibited the migration of A375 cells, and reduced tumor volume in a mouse xenograft model of MM (Chen et al. 2016a, b). This evidence concerns the gene GAS5 and neoplasm.