IFNG and Thrombocytopenia: - Depleting macrophages or abrogating IFN-γ signaling in macrophages did not impair T-cell activation or IFN-γ production in the BM but rescued HSCs- Macrophages are not required for induction of IFN-γ in SAA and rather act as sensors of IFN-γ- Macrophage depletion rescued thrombocytopenia, increased BM megakaryocytes, preserved platelet-primed stem cells, and increased the platelet-repopulating capacity of transplanted HSCs