Esposito et al. introduced the conjugate of the let-7g passenger strand to the 3′ end of the GL21.T aptamer (tyrosine kinase receptor ligand) by using 17bp stick-base, and then, by annealing of the complementary guide strand of the miRNA, showed an efficient delivery of let-7g to target cancer cells (26). The gene discussed is NTRK1; the disease is cancer.