Treatment of cells with various stimuli e.g., insulin (53), insulin-like growth factor-I (57), epidermal growth factor (58), arsenic (59), cAMP or agonists that increase intracellular cAMP levels (60–64) leads to S2152 phosphorylation of FLNa in epithelial, platelets, smooth muscle cells, cancer cells and fibroblasts, respectively. The gene discussed is INS; the disease is cancer.