To report the clinical and immunological characteristics of 22 new patients with GFAP-IgG. GFAP autoimmunity is not rare. The clinical spectrum encompasses meningoencephalitis, myelitis, movement disorders, epilepsy and cerebellar ataxia. coexisting neurological and systemic autoimmunity are relatively common. Immunotherapy is beneficial in most cases. Here, GFAP is linked to cerebellar ataxia.