This study demonstrates CSF GFAPα-IgG is a specific autoimmune meningoencephalomyelitis biomarker, with favorable corticosteroid response. Lack of response should prompt evaluation for co-existing NMDA-R-IgG or malignancy.This study found that spinal cord lesions in GFAP-IgG myelitis were commonly longitudinally extensive (≥80%) and centrally located. Compare to AQP4-IgG lesions, they were more subtle lesions with poorly defined margins and less swelling. In GFAP-IgG myelitis, spinal cord central canal, punctate or leptomeningeal enhancement was typical. This evidence concerns the gene AQP4 and myelitis.