Also, our data indicate that TIGIT and PD-1 are up-regulated on what we cautiously define as “activated/exhausted” cell subsets, and the PD-1+ TIGIT+ CD160+ (triple positive) T cells are elevated with aviremic HIV infection and not healthy aging, suggesting that HIV drives further progression of γδ T cell populations along activation/exhaustion routes. Here, CD160 is linked to HIV infectious disease.