TARDBP and amyotrophic lateral sclerosis: A moderate association between the amount of poly(GA) dystrophic neurites and degeneration in the frontal cortex was observed (40), and inclusions of poly(GR), which is especially toxic in in vitro models (42), correlated with TDP-43 pathology and neurodegeneration in C9+ FTD-ALS brains (7, 41).