Nevertheless, the presence of DPR protein aggregates and RNA foci did not lead to TDP-43 accumulation in a neurologically healthy mosaic carrier (43), and DPR protein pathology with little, if any, TDP-43 pathology was observed in a c9FTD kindred with early intellectual disability (44) and three C9orf72 mutation carriers who developed relatively rapid cognitive decline but died prematurely due to unrelated illness (45). Here, TARDBP is linked to Intellectual disability.