FKBP5 and stress-related disorder: In humans, genetic variations of the FKBP51-encoding gene FKBP5 that were shown to enhance expression of FKBP51 (Klengel et al., 2013) are associated with various stress-related disorders, especially in an environmental background of early life trauma (Klengel et al., 2013; Zannas and Binder, 2014; Zannas et al., 2016).