Inspired by the well-established role of FKBP51 as a suppressor of the glucocorticoid receptor as well as its involvement in the nuclear factor “kappa-light-chain-enhancer” of activated B-cells (NF-κB) pathway, a research group from Boehringer Ingelheim recently explored the role of FKBP51 in models of glucocorticoid-resistant asthma (Kastle et al., 2018). This evidence concerns the gene FKBP4 and asthma.