CDH1 and signet ring cell carcinoma: Using careful white-light examination with targeted biopsies and 24 random biopsies (4 each of the prepylorus, antrum, T zone, body, fundus, and cardia) combined with detailed histopathology, Lim et al (van der Post et al., 2015a) found signet ring cell carcinomas in 14 of 22 patients with, and 2 of 7 patients without, CDH1 mutations fulfilling the 2010 HDGC criteria.