Endothelial WNT-β-catenin has been previously shown to be sufficient to induce PDGF-B expression and enhance pericyte coverage in brain tumors (Reis et al., 2012) however, to our knowledge, our studies using Pdgfbicre; Ctnnb1LOF and Pdgfbicre; Ctnnb1GOF mutants are the first to look at this in the developing brain vasculature. Here, PDGFB is linked to brain neoplasm.