Another mouse model of ASD carrying a point mutation in neuroligin 3 (NLGN3) showed increased GABAergic transmission, while mouse model for Rett syndrome (where neurons were depleted of MeCP2) showed decreased GABAergic transmission without affecting glutamatergic transmission (Chao et al., 2010). The gene discussed is NLGN3; the disease is atypical Rett syndrome.