Moreover, the loss of function of maternally inherited UBE3A is also associated with Angelman syndrome (AS), a neurodevelopmental disorder with severe mental retardation along with autistic features (Malzac et al., 1998; Moncla et al., 1999), thus making UBE3A a potential candidate gene to be studied for better understanding of autism. This evidence concerns the gene UBE3A and neurodevelopmental disorder.