Recent data further indicates that patients with moderate-to-advanced sporadic AD appear to have a significantly higher population of LPS-enveloped nuclei, and a correspondingly lower amount of NF-L associated with that region of the AD brain (Zhao et al., 2017b; Zhao and Lukiw, 2018) (Figures 5, 6). The gene discussed is NEFL; the disease is Alzheimer disease.