The concordant expression of ABCB1 and other potential drug-resistant genes in docetaxel-resistant breast cancer cells indicates that besides ABCB1, there are also other genes that may play an important role in the generation of docetaxel resistance, and these genes may contribute to docetaxel resistance in a cooperative way with ABCB1. Pathway enrichment with the genes in this module highlighted the important roles of the PI3K-Akt and ABC transporter signaling pathways. This evidence concerns the gene AKT1 and breast cancer.