GSN and hydrops fetalis: In response to advanced pressure-overload, gelsolin-knockout (GSNKO) mice, which do not show any detectable difference in the normal state as compared to wild-type (WT) mice, had markedly reduced HF-related mortality compared with WT mice (Fig. 1i), correlating with reduced ventricular dilation (Fig. 1j) and pulmonary edema (Fig. 1k and Supplementary Data 1).