Importantly, in an in vivo ovarian cancer xenograft model, CAFs were found to be remarkably enhance the metastatic ability of ovarian cancer cells with increased metastatic nodules in the peritoneal cavity; however, the inhibition of TGF-β1 signaling attenuated the metastatic dissemination of ovarian cancer. The gene discussed is TGFB1; the disease is ovarian carcinoma.