STAT3 and ovarian cancer: Furthermore, previous studies have revealed that intraperitoneal M2-polarized macrophages induce the activation of the signal transducer and activator of transcription 3 (STAT3) in ovarian cancer cells and that STAT3 signaling is intimately involved in cell–cell interactions between cancer cells and M2 macrophages, which stimulate the proliferation and metastatic progression of ovarian cancer cells [106].