Mechanistically, elevated levels of ErbB3, which is a member of the epidermal growth factor (EGF) receptor (EGFR) family, in circulating ovarian cancer cells and neuregulin 1, which is an ErbB3 ligand, in the omentum have been shown to play functional roles in the hematogenous spread of ovarian cancer with metastatic tropism for the omentum [37]. This evidence concerns the gene ERBB3 and ovarian cancer.