Furthermore, our comprehensive in vitro studies have clearly identified the pivotal role of adipocyte-activated SIK2 in the promotion of fatty acid oxidation via the augmentation of the AMPK-induced phosphorylation of acetyl-CoA carboxylase (ACC) and the activation of carnitine palmitoyltransferase 1 (CPT1) transcription during the metastatic progression of ovarian cancer [54]. This evidence concerns the gene SIK2 and ovarian carcinoma.