Furthermore, M2 subtype TAMs secrete a large amount of EGF that activates EGFR on spheroid-associated ovarian cancer cells, which in turn upregulates VEGF-C/VFGF receptor 3 (VEGFR3) signaling and induces integrin/intercellular adhesion molecule 1 (ICAM-1) expression in the surrounding tumor microenvironment as a positive autocrine feedback loop to promote cancer cell proliferation and migration. Here, EGFR is linked to ovarian carcinoma.