After undergoing coevolution with ovarian cancer cells, activated omental adipocytes increase the secretion of various types of adipokines, such as interleukin-6 (IL-6), IL-8, monocyte chemoattractant protein-1 (MCP-1), tissue inhibitor of metalloproteinase-1 (TIMP-1), and adiponectine, and these adipokines promote the multistep process of ovarian cancer dissemination with metastatic tropism for the omentum. Here, TIMP1 is linked to ovarian cancer.