Recent studies have shown that signaling pathways regulated by TLRs, CSF1R, PI3Kγ, and BTK control macrophage polarization8–15; here, we showed that CD11b promotes miRNA Let7a expression and inhibits Myc expression to control of macrophage polarization and tumor immune responses (Schematic, Fig. 5m). The gene discussed is CSF1R; the disease is neoplasm.