Herein, we identify that CRC-derived exosomal miR-25-3p can be transferred to vascular endothelial cells and thereby promotes vascular permeability and angiogenesis by targeting Krüppel-like factor 2 (KLF2) and Krüppel-like factor 4 (KLF4). This evidence concerns the gene KLF4 and colorectal carcinoma.