Obviously, the luciferase activities of KLF2 and KLF4 3′ UTR were dampened by SW480/miR-25-3p exosomes, but not SW480/mock exosomes, indicating that KLF2 and KLF4 in HUVECs can be silenced by exosomal miR-25-3p derived from CRC cells (Supplementary Figure 5A, B). This evidence concerns the gene KLF4 and colorectal carcinoma.