CTLA4 and metastatic melanoma: Immune checkpoint blockade with monoclonal antibodies against cytotoxic T lymphocyte antigen 4 (CTLA-4) and programmed cell death protein 1 (PD-1) or their ligands, such as PD1 ligand 1 (PD-L1) has revolutionized the treatment of metastatic melanoma patients with the possibility of durable and long-lasting responses [1].