ABCA1 and hypertriglyceridemia: On the contrary, another study found enhanced cholesterol efflux among 45 patients with T2DM and hypertriglyceridemia compared to 26 patients with T2DM without hypertriglyceridemia, suggesting that high triglycerides in T2DM might produce a compensatory effect to maintain ABCA-1 efflux, although the mechanism is not entirely clear [31].