ALB and colorectal carcinoma: While the likelihood of drug absorption has been described in compliance to the Ro5, Veber rule, human intestinal absorption (HIA), skin permeability (logKp), colorectal carcinoma (Caco2) and Madin-Darby canine kidney (MDCK) cells permeability, the drug distribution was modeled using the blood/brain partition coefficient (BBB) and the coefficient of binding to human serum albumin (PPB).