FADS1 and neoplasm: In addition, while 5-FU treatment alone was able to suppress the growth of both delta-5-desaturase-WT and delta-5-desaturase-KD tumors (Fig. 4, Additional file 2: Table S1 and Additional file 3: Table S2), a two-factor analysis (considering 5-FU and delta-5-desaturase-KD/dihomo-γ-linolenic acid as the factors, Additional file 4: Table S3) suggested an additive effect on tumor inhibition from the combination of 5-FU and delta-5-desaturase-KD/dihomo-γ-linolenic acid.