In addition, while treatment with 5-FU alone suppressed tumor proliferation in both delta-5-desaturase-WT and delta-5-desaturase-KD tumors, the combination of dihomo-γ-linolenic acid supplementation and 5-FU in delta-5-desaturase-KD tumors resulted in slightly less Ki-67 expression. Here, FADS1 is linked to neoplasm.