FADS1 and neoplasm: We have demonstrated that dihomo-γ-linolenic acid supplementation elevated 8-hydroxyoctanoic acid production in an autocrine manner to a threshold level (> 0.3 μg/g) in delta-5-desaturase-KD tumors and therefore significantly suppressed tumor growth (~ 40% reduction vs. delta-5-desaturase-WT tumor control).