SMAD4 and cancer: By comparing our findings to 578 known driver genes from the COSMIC database [30], we found that among the 35 genes, 12 of them are known cancer driver genes (EPHA3, TRIM24, BRAF, LIFR, PTEN, NTRK3, FBXW7, ARID1A, TP53, JUN, CHCHD7, SMAD4).