Varis et al. used GC xenografts and four GC cell lines to confirm that 11 genes within 17q12–21 region were amplified within the genome (ERBB2, TOP2A, GRB7, ACLY, PIP5K2B, MPRL45, MKP-L, LHX1, MLN51, MLN64, and RPL27) [34]. This evidence concerns the gene CASC3 and gastric cancer.