In particular, 30 somatic SNVs were confirmed in 28 genes (TRIM24, LIFR, EPHA3, FOXG1, ABCC4, PTEN, SOX5, AKAP13, NTRK3, KLK10, FBXW7, ABCB1, LRP6, ARID1A, LIG3, TP53, ACTN4, LEF1, TLR2, PKHD1, CSMD1, CYP24A1, BCR, ITGAX, PTK7, SLCO1B1, JUN, CHCHD7) for both the primary tumors and lymph node metastatic tissues, and 7 mutations unique to the primary tumor tissues. The gene discussed is SOX5; the disease is neoplasm.