TOP2A and gastric cancer: Varis et al. used GC xenografts and four GC cell lines to confirm that 11 genes within 17q12–21 region were amplified within the genome (ERBB2, TOP2A, GRB7, ACLY, PIP5K2B, MPRL45, MKP-L, LHX1, MLN51, MLN64, and RPL27) [34].