Therefore, the research aimed to explore the reliability indicators combination including risk (C) allele of the SNP (rs2275294) in the ZNF512B gene, neck flexor muscle power and body mass index, in order to establish reasonable pattern for ALS prognosis, and furthermore to imply appropriate medical intervention and health care as early as possible. The gene discussed is ZNF512B; the disease is amyotrophic lateral sclerosis.