In this study, we report that MAFA co-expression correlations in human islets are much stronger and are associated with a higher number of genes within cytokine signaling and T1D genetic risk spectrum than MAFB, indicating that MAFA has a unique role in regulating the expression of these immune modulatory genes directly and indirectly through interferon-induced positive feedback loops. This evidence concerns the gene MAFB and type 1 diabetes mellitus.