Moreover, modulations of gene expression affect major regulators of HCC, such as c-myc, cyclin A2, cyclin D1, retinoblastoma 1, Axin1, insulin-like growth factor-II receptor/mannose-6-phosphate receptor, p16INK4a, Yes-associated protein (YAP)1, E-cadherin, suppressors of cytokine signaling (SOCS), interleukin (IL)-6, phosphatase and tensin homolog, or cyclooxygenase 2 in HCC [14,15]. This evidence concerns the gene CISH and hepatocellular carcinoma.