Moreover, as stated before, children born with a missense homozygote mutation in one of genes coding for the proton pump and thus being anacidic and hypergastrinemic from birth, developed ECL cell NETs and gastric carcinoma at young age [38,39] further substantiating the central role of gastrin and the ECL cell in gastric carcinogenesis. This evidence concerns the gene GAST and gastric carcinoma.