PPARA and Hepatic steatosis: There may be multiple mechanisms of ethanol-induced fatty liver as mentioned above: ethanol administration results in the activation of SREBP-1c and ChREBP, which promotes de novo fatty acid synthesis; an increase PPARγ and acyl-CoA:diacylglycerol acyltransferase mRNA expression promotes TG synthesis; and decreases in PPARα and CPT1 mRNA expression, which leads to the inhibition of fatty acid oxidation [29].