Several splicing defaults and transcriptional alterations have been described in DM1 patients and in different DM1 models including Drosophila. In adult DM1 flies expressing 480 CTGs, among genes involved in muscle development Z band alternatively spliced PDZ-motif protein 52 (Zasp52), ortholog of LDB3 in human, encoding a Z-band component was found aberrantly spliced [37] and could contribute to the disorganization of the sarcomere and Z-band disruption, also reported in DM1 patients [38]. The gene discussed is LDB3; the disease is myotonic dystrophy type 1.