The capacity of Mbnl1 to rescue the main DM1 symptoms is also observed in the Drosophila DM1 model, where cardiac overexpression of Muscleblind (Mbl), the Drosophila Mbnl1 ortholog, is sufficient to rescue the heart dysfunctions and reduced survival of DM1 flies [29]. This evidence concerns the gene MBNL1 and myotonic dystrophy type 1.