CELF1 and Steinert myotonic dystrophy: Another recent study reporting transcriptional profiling of the cardiac DM1 models [59] revealed that the inhibition of mbl or overexpression of Bru-3 specifically in the fly heart, that mimic the pathogenic MBNL1/CELF1 misbalance in DM1 patient, induce asynchronous heartbeat and cardiac arrhythmia (Figure 1).