PHB1 and obesity due to melanocortin 4 receptor deficiency: A mutant (m)Mito-Ob mouse model that overexpresses a phospho-mutant PHB (Y114F) under the aP2 promoter also developed obesity and diabetic symptoms, but instead manifested lymphoproliferative disease (lymph node tumors) or adult onset autoimmune diabetes when fed on HFD [158].