KRAS and pancreatic neoplasm: Okumura group found that genetically engineered mice with Pdx1, Kras or Trp53 mutations fed on HFD had significantly larger primary pancreatic tumors and higher distant organ metastasis; in vitro, FFAs from visceral adipose tissue-derived conditioned media also increased lipid droplets in the pancreatic cancer cells and enhanced cell invasiveness [56].