PDGFRB and central nervous system cancer: Although, it was reported that, both in glioma cell lines and primary GB tumor tissues, express platelet-derived growth factor (PDGF)-DD protein, a ligand able to activate mitogenic pathways in these cells through platelet-derived growth factor receptor beta (PDGFR this growth factor alerts tumor-infiltrating innate immune cells through engagement of NKp44, present in GB infiltrating NK cells.