Apart from the well-known implication of mutations affecting the NOX2 complex in the pathogenesis of chronic granulomatous disease (CGD) [33], some information is currently available in the literature on the possible predisposing role of polymorphisms in NCF1, NCF2, NCF4, CYBA, and CYBB genes in other immune disorders. The gene discussed is NCF4; the disease is chronic granulomatous disease.