For investigating the potential role of OS genes in the pathogenesis of MS, we performed an association analysis on a Finnish cohort of 63 MS families (547 individuals) with two microsatellite markers and 11 SNPs mapping in or located close to the five genes coding for the main components of the NOX2 complex (the soluble factors NCF1, NCF2, and NCF4, and the membrane-bound redox core proteins of the complex, CYBA and CYBB) (see Table S1 in the Supplementary Materials). This evidence concerns the gene CYBB and myeloid sarcoma.