WARS2 and hypertrophic cardiomyopathy: These differences were also observed in compound heterozygote Wars2V117L/− mice, which showed increased LVAW and LV mass and decreased CO relative to Wars2+/+, Wars2+/V117L, and Wars2+/− mice at the same age, regardless of Tchh genotype (Figure 3D), confirming that the Wars2V117L allele was the causal mutation for hypertrophic cardiomyopathy.