Examination of previously published genome-wide significant loci from Han Chinese PCOS [14,15] demonstrated that index variants from the THADA, FSHR, C9orf3, YAP1 and RAB5B loci were significantly associated with PCOS after Bonferroni correction for multiple testing in our European ancestry subjects (S5 Table). This evidence concerns the gene AOPEP and polycystic ovary syndrome.