FTO and type 2 diabetes mellitus: Second, by in silico replication using SUMMIT consortium data for type 2 diabetes, the association of FTO variants with diabetic nephropathy was not replicated in European patients with type 2 diabetes (Table 3, S7 Table), and the association of FTO variants with diabetic nephropathy showed a genome-wide significant association only in a joint analysis for the discovery stage; therefore, these observations may not be in line with standards for GWA studies; further study, such as a large-scaled longitudinal study, is required to elucidate the association of FTO locus with diabetic nephropathy.