The association of rs56094641 in FTO with overt nephropathy was still genome-wide significant level after integration of all association data (P = 7.62 × 10−10, OR = 1.21, 95% CI 1.14−1.29, Table 3) though the association was not statistically significant in the replication study alone (P = 0.258, OR = 1.11, 95% CI 0.93−1.32, Table 3). This evidence concerns the gene FTO and kidney disorder.