To investigate the underlying causes of steatosis associated with Smurf1 loss, we compared hepatic gene expression profiles of 11-month-old Smurf1KO, Smurf2KO, and their respective matching WT mice from the BL background, and selected genes that showed either increased or decreased expression by a cutoff of 1.5-fold (false discover rate [FDR] <0.1). The gene discussed is SMURF1; the disease is steatosis.