Consistent with previous studies, the most commonly mutated genes in this study were the DNA methyltransferase DNMT3A and the DNA demethylase TET2. The prevalence of CHIP appears to be significantly higher in the study cohort compared with previously published data in age-matched healthy participants2 or patients with coronary artery disease.4Indeed, experimental studies8,9 disclosed that both TET2 and DNMT3A loss-of-function in murine hematopoietic stem cells promote cardiac dysfunction in murine models of heart failure. Here, TET2 is linked to heart failure.