However, compared with published cohorts of unselected populations2 as well as patients with coronary heart disease,4 the frequency of identified mutations was considerably higher in all age groups, with 10% of patients between age 50 and 59 years (5 of 50), 20.9% between age 60 and 69 years (14 of 67 patients), and 26.6% between age 70 and 79 years (17 of 64 patients) harboring CHIP-related mutations (Figure 1A). The gene discussed is STUB1; the disease is coronary artery disorder.