What's more, it's also been reported that up‐regulation of MEG3 in prostate cancer cell lines induces cell apoptosis and G0/G1 phase arrest.16 The results of our study focused on detecting the effect of lncRNA MEG3 in PCa, we revealed that MEG3 was a down‐regulated lncRNA in PCa and it played a role of anti‐cancer factor. Here, MEG3 is linked to Familial prostate cancer.